The latest updates from the Phylogica team


Phylomer Libraries: A Rich Source of Peptide Hits in Phenotypic and Target-Directed Screens

The Royal Society of Chemistry, 17: 497-517

Paul M Watt, Tatjana Heinrich, Robert E Dewhurst, Shane R Stone, Richard W Francis, Renae K Barr, Heique M Bogdawa and Nadia Milech

Structure-diverse Phylomer libraries as a rich source of bioactive hits from phenotypic and target directed screens against intracellular proteins

Chemical Biology 2017, 38:127-133

Paul M Watt, Nadia Milech and Shane R Stone

GFP-complementation assay to detect functional CPP and protein delivery into living cells.

Scientific Reports, 1-11.

Milech, N., Longville, B.A., Cunningham, P.T., Scobie, M.N., Bogdawa, H.M., Winslow, S., et al.

Poly-arginine and arginine-rich peptides are neuroprotective in stroke models.

Journal of Cerebral Blood Flow & Metabolism. Epub 11 Feb 2015

Meloni BP, Hoffmann K, Hopkins RM et al

The Neuroprotective Efficacy of Cell- Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Culture

Cellular and Molecular Neurobiology ISSN 0272-4340 Cell Mol Neurobiol DOI 10.1007/s10571-013-9999-3

Bruno P. Meloni, Amanda J. Craig, Nadia Milech, Richard M. Hopkins, Paul M. Watt, et al.

A novel retro-inverso peptide is a preferential JNK substrate-competitive inhibitor.

The International Journal of Biochemistry & Cell Biology 45, 2013, Epub 19 Jun 2013

Ngoei KRW, Catimel B, Milech N., Watt PM, Bogoyevitch MA

The Construction of “Phylomer” Peptide Libraries as a Rich Source of Potent Inhibitors of Protein/Protein Interactions.

Therapeutic Proteins: Methods and Protocols, second edition, Eds: Voynov V and Caravella J. Springer, Humana Press 2012

Milech N and Watt P

Lack of neuroprotection of inhibitory peptides targeting Jun/JNK after transient focal cerebral ischemia in spontaneously hyperactive rats.

Journal of Cerebral Blood Flow & Metabolism 2011 Dec; 31 (12), Epub 5 Oct 2011.

Gow WR, Watt P, Milech N, et al

Characterization of a novel c-Jun N-terminal Kinase (JNK) inhibitory peptide.

Biochem Journal 2011, 434, 399-413

Ngoei K, Watt P, et al

Attenuation of Neuronal Death by Peptide Inhibitors of AP-1 Activation in Acute and Delayed In Vitro Ischaemia (Oxygen/Glucose Deprivation) Models.

International Journal of Peptide Research and Therapeutics, March 2011, Volume 17, Issue 1, pp 1-6, Online on 4 Nov 2010

Craig AJ, Meloni BP, Watt P, Knuckey NW

AP-1 inhibitory peptides are neuroprotective following acute glutamate excitotoxicity in primary cortical nueronal cultures

Journal of Neurochemistry 2010 vol 112, 258-270

Meade AJ, Watt P et al

AP-1 inhibitory peptides attenuate in vitro cortical neuronal cell death induced by kainic acid.

Journal of Brain Research 11 Nov 2010, Epub 15 Sep 2010

Meade AJ, Watt P et al

Phenotypic screening of phylomer peptide \ ~ libraries derived from genome fragments to identify and validate new targets and therapeutics

Phenotypic Screening Review FutureMed. Chern. (2009) 1(2). 257-265

Watt P

A peptide inhibitor of c-Jun provides wound healing in a mouse full-thickness burn model

Wound Repair and Regeneration, 2008, Vol 16, 58-64

Giles N, Rea S, Beer T, Wood FM, Fear MW

Protein silencing with Phylomers: a new tool for target validation and generating lead biologicals targeting protein interactions.

Expert Opinion Drug Discov 1(5) 2006

PM Watt, TK Heinrich, WR Thomas

Screening for peptide drugs from the natural repertoire of biodiverse protein folds.

Nature Biotechnology Vol 24 (2):177-83 Feb 06.

PM Watt

Reverse two-hybrid screening identifies residues of JNK required for interaction with the kinase interaction motif of JNK-interacting protein-1

J Biol Chem. 2004 Oct 8;279(41):43178-89. Epub 2004 Jul 22.

Barr RK, Hopkins RM, Watt PM, Bogoyevitch MA.


The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK.

Biol Chem. 2004 Aug 27;279(35):36327-38. Epub 2004 Jun 18.

Barr RK, Boehm I, Attwood PV, Watt PM, Bogoyevitch MA.